data monitoring committee การใช้

• Calculations involving the joint distribution are needed to correctly maintain the error rate when the data are examined multiple times within a study by a Data Monitoring Committee.
• Angioplasty resulted in a 40 percent reduction in death, recurrent heart attack or stroke after 30 days . The data were compelling enough that the study was stopped early by a data monitoring committee.
• An interim analysis performed in October 7 led the Data Monitoring Committee to support a recommendation to stop the study as the totality of evidence suggested that evacetrapib was unlikely to be superior to placebo.
• The DAHANCA 10 data monitoring committee found that 3-year loco-regional control in subjects treated with Aranesp was significantly worse than for those not receiving Aranesp ( p = 0.01 ).
• The DAHANCA 10 data monitoring committee found that three-year loco-regional cancer control in subjects treated with Aranesp was significantly worse than for those not receiving Aranesp ( p = 0.01 ).
• Based on his methodological and clinical research expertise, Prof . Sch鰂fski is member of ( or coordinates ) a number of Independent Data Monitoring Committees for ongoing and completed Phase II / III clinical trials in collaboration with academic groups, biotech companies, clinical research organizations and pharmaceutical companies.
• He has served and continues to serve and on several data monitoring committees of major clinical trials, including Gusto, ECLA, ASCOT, ADVANCE, EUCLID, MODEST, CREATE, OASIS 5-7, COMMIT, VALUE, PACE, SCOUT, RELY, ORIGIN, GISSI-HF, ONTARGET, TRANSCEND and PrOFESS.
• The ALSYMPCA study was stopped early after a pre-planned efficacy interim analysis, following a recommendation from an Independent Data Monitoring Committee, on the basis of achieving a statistically significant improvement in overall survival ( two-sided p-value = 0.0022, HR = 0.699, the median overall survival was 14.0 months for 223 Ra and 11.2 months for placebo ).